http://dspace.ewubd.edu:8080/xmlui/handle/123456789/1451 2026-04-23T14:09:48Z http://dspace.ewubd.edu:8080/xmlui/handle/123456789/2664 Identification Of Socio-Demographic And Behavioral Risk Factors Of Oral Cancer In Rural And Urban Areas Of Bangladesh Hossain, Tanjina Abstract: This study was conducted as a cross sectional survey in the National Institute of Cancer Research and Hospital, Dhaka Bangladesh. A questionnaire was designed and comprised of relevant questions to determine socio-demographic information, awareness and knowledge of oral cancer and risk factors and questions on participant’s exposure to risk factors were also included. Method: Subjects above the age of 30 years (n=114) were randomly selected during the period from 1 June 2016 to October 2017. The questionnaire was distributed to complete while they were waiting for their treatment at the National Institute of Cancer Research and Hospital (NICRH). Data was analyzed using Microsoft Excel 2010 and statistical package Result: The study revealed that, female adult was more susceptible to oral cancer than male. The mean age of the participants was 48.7 ± 10.8 years ranging from 30 to 85. Among the 114 patients, 85% came from rural areas and 69% of those population found illiterate. From the study we found that, tobacco smoking, smokeless tobacco (betel leaf, betel nut, quid chewing, jorda, gull) and alcohol was the major risk factors of oral cancer. Also, sun or radiation exposure and fungal infection was identified as a risk factors of oral cancer. In this study, we also found that local factor such as faulty teeth, sharp teeth, loose teethe and denture are important factor for oral cancer. As a sign and symptom, non-healing mouth ulcer and Lump in neck could be major signs of oral cancer. Among these all cancer patients, 38.6% were affected in buccal mucosa, 25.44% were affected in alveolar region and few of them are in lip (14.04%). The study shows that TNM stage of most patients were T2N1Mx, T2N3Mx that means tumor size 2 to 6 cm and cancer cell present in lymph node and metastasis information could not be assessed. Our study about chemotherapeutic treatment indicate that 5-flurouracil, Paclitaxel, Cisplatin and Carboplatin are most commonly use in Oral Cancer. Conclusion: At current circumstance, all through the world and our nation, number of oral cancer patient increased day by day. Respondents were found having a low level of knowledge scores on the risk factor, sign and symptoms, diagnosis and treatment of oral cancer. The present investigation primarily gives a thought that there might be some connection between oral cancer and different risk factors. This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh. 0012-01-01T00:00:00Z http://dspace.ewubd.edu:8080/xmlui/handle/123456789/2663 A survey on skin disease and its impact on Quality of life Khatun, Most. Hajera Skin disease is one of the common human illnesses It is a multidimensional concept that encompasses psychological, social and financial consequences of the skin disease on the patients, their families and on society. Chronic and incurable skin diseases, such as allergy, psoriasis, fungal infection and eczema, are associated with significant morbidity in the form of physical discomfort and impairment of patients' quality of life. The aim of the study was to explore the level of awareness of risk factors related to skin disease and its impact on quality of life (QoL) in different Govt hospital patients in Bangladesh. A pre-structured questionnaire was used to collect data from 181 patients from skin departments in four hospitals of different cities of Bangladesh. In this study purposive sampling technique was followed. The study represents the distribution of the patients according to their age where highest no. of patient (72.92%) were in the age group of 19-45 years followed by <18 year age group (16.02%). The majority (67.95%) of the patients belonged to middle socioeconomic class with monthly income within Tk.10,000-40,000 BDT and observed that major portion (35.91%) of the patients completed their primary education. On the other hand, 16.57% patients studied up to H.S.C and 13.81% patients were Graduate. Majority (63.54%) of the patients were male and 36.46% of the patients were female and maximum (48.07%) patients identified bad hygiene as the risk factors of skin infection followed by wearing tight cloth (27.07%), lack of sleep (17.67%), drinking less water (10.49%) etc. During the study it was seen that 43.65% of patients had oily skin and 35.91% of patient had dry skin. On the other hand, only 11.60% had normal skin. The prevalence of skin disease among adults was found to be 72.92% with allergy, psoriasis & fungal infection being the most common. Among the population 71.27% of the patients were mostly suffered by skin disease during the summer season. Awareness of skin disease is under-researched in Bangladesh, and a deep understanding remains to be achieved. Thus, there is a need for further studies on community health education and treatment individualization for skin disease. This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh. 0002-01-01T00:00:00Z http://dspace.ewubd.edu:8080/xmlui/handle/123456789/2644 A Study on Lipid Profile Pattern of patients with Diabetes Mellitus and relationship with Blood Pressure, Serum Creatinine level and HbA1c Sultana, Shahria This study reviews the relationship between dyslipidemia, chronic kidney disease, and cardiovascular diseases in patients with diabetes. Diabetes mellitus is associated with complications in the cardiovascular and renal system, and is increasing in prevalence worldwide. Modification of the multifactorial risk factors, in particular dyslipidemia, has been suggested to reduce the rates of diabetes-related complications. Dyslipidemia in diabetes is a condition that includes hypertriglyceridemia, low high-density lipoprotein levels, and increased small and dense low-density lipoprotein particles. This condition is associated with higher cardiovascular risk and mortality in diabetic patients. Current treatment guidelines focus on lowering the low-density lipoprotein cholesterol level; multiple trials have confirmed the cardiovascular benefits of treatment with statins. Chronic kidney disease also contributes to dyslipidemia, and dyslipidemia in turn is related to the occurrence and progression of diabetic nephropathy. This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh. 0002-01-01T00:00:00Z http://dspace.ewubd.edu:8080/xmlui/handle/123456789/2643 Compatibility Study of Albendazole, Levofloxacin and Pregabalin with Various Excipients and their Subsequent Formulation Optimization Haque, Mahjabin This work was proposed to assess the compatibility of Actives viz. Albendazole, Levofloxacin and Pregabalin with different functional excipients like fillers/diluents, disintegrants, binders and lubricants which are commonly used in solid dosage formulation. Samples were made by mixing active and excipients in different ratio and put in stability chamber at different stability conditions. Samples were withdrawn at different time intervals and tested accordingly. Assay, Impurity and IR spectrum were chosen as testing parameter to determine the compatibility of actives with particular excipient. This research work has demonstrated the relationship between active and excipients and their compatibility in dosage form formulation. Tentative formula of the dosage forms viz. Albendazole Chewable Tablets, Levofloxacin Film Coated Tablets and Pregabalin Capsules were also established and evaluated. This thesis submitted in partial fulfillment of the requirements for the degree of Masters of Pharmacy (M.Pharm) in East West University, Dhaka, Bangladesh. 0011-01-01T00:00:00Z