http://dspace.ewubd.edu:8080/xmlui/handle/123456789/1458 2026-04-04T12:56:31Z http://dspace.ewubd.edu:8080/xmlui/handle/123456789/1636 In Vitro Pharmacological Investigations of Petroleum Ether Fraction of Ficus Racemosa Leaves Extract Voumik, Suvrota The purpose of the study was to evaluate the cytotoxic, antimicrobial and antioxidant activity of ethyl acetate fraction of Ficus racemosa (Family: Moraceae) leaves extract.The powdered leaves of Ficus racemosa were extracted with methanol and then partitioned with DCM, petroleum ether,ethyl acetate, and aquous consecutively. The petroleum ether fraction was used to evaluate cytotoxic, antimicrobial and antioxidant activities. The cytoxic activity was measured by brine shrimp lethality bioassay. The antimicrobial activity was assessed by disc diffusion method. Ethyl acetate fraction showed cytotoxic activity with LC50value 23μg/ml in brine shrimp lethality test. In antimicrobial activity investigation the ethyl acetate fraction showed low to moderate antibacterial and antifungal activity against the tested organism compared to the azithromycin (22.9μg/disc) that was used as positive control. The fraction contained 40.01mg AAE/g of total phenolic content and 435mg AAE/g total flavonoid content. The results of study clearly indicate the presence of cytotoxic, antimicrobial and antioxidant properties of petroleum ether extract. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation. This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh 0012-01-01T00:00:00Z http://dspace.ewubd.edu:8080/xmlui/handle/123456789/1628 Antimicrobial and Antioxidant Investigations of Methanolic Extract of Dracaena spicata Monni, Ayesha Siddika Indigenous knowledge of herbal medicines for skin diseases like boils, eczema, scabies, septic abscess, itching and skin allergy, burns, chicken pox, warts and leucoderma, fungal and bacterial infections, including healing cuts and wounds has been documented by randomly interviewing Chakma, Marma and Tanchunga tribes of the hill tracts districts of Bangladesh since 1995. The plant Dracaena spicata has been used for the general promotion of health and longevity by Asian tribal(specially Chakma, Marma and Tanchunga). It is used as a traditional medicine for the treatment of various diseases cough, syphilis , conjunctivitis, constipation, pills prepared from the leaves are taken with warm water twice daily for the treatment of measles by the Chakma etc. The aim of the present study was to evaluate the antimicrobial activity and antioxidant activity of methanolic extract of Dracaena spicata. The antimicrobial activities of methanolic solvent extract of Dracaena spicata plant were tested against the gram-positive and gram-negative bacterial strains by observing the zone of inhibition. The antimicrobial test was performed by disc diffusion method. The crude methanolic extract of Dracaena spicata plant showed poor antimicrobial activities against the microorganisms at concentrations of 600 μg/disc. However, no activity was found against Bacillus megaterium, Salmonella paratyphi. The antioxidant effect of methanolic extract of Dracaena spicata was determined by calculating reducing power of the content. Reducing power was determined by using ascorbic acid as standard. By determining antioxidant property, the present result suggests that the tested plant extracts have potent antioxidant activity. In conclusion, further investigations are needed to identify the active constituents and the exact mechanism(s) of action responsible for the reported antimicrobial and antioxidant properties of Dracaena spicata. This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh. 0012-01-01T00:00:00Z http://dspace.ewubd.edu:8080/xmlui/handle/123456789/1626 A Survey on Socio-Demographic and Health status of Tribal Community of Bangladesh: Santals Abdullah, Nawfel Purpose: There is lack of evidence based information particularly in Bangladesh about the status of health and disease condition of different tribal community, especially about Santals. The study was performed so that the critical aspect and condition of health of the Santals along with their socio-demographic status has been revealed. Methods: Study was conducted at the Rajshahi Division, in the Naogaon district in six different village where the Santals lives from their ancestors. Information on their socio-demography, health, disease condition and others related matters has been collected through a pre-planned questionnaire and the collected data were analyzed to reveal the desire status through Excel and SPSS analysis. Result: On the basis of critical analysis, the highest age of the participants were 86 and the lowest were 15, and the mean (±SD) age of the participants were 38.25 (±15.313) years. The percentage of male and female participants were 45.9% and 54.1% respectively. There dependency on their hand made alcohol were notable 39.8%, and smoking were 43.2%, among them percent female alcoholic were 14.5%. Maximum participants were having high blood pressure 73.7% whereas the percent among male and female were 80% and 67.8% accordingly. The prevalence of diabetes were 34.1%, where the percent of male and female were 52.56% and 47.44%. In addition, percentage and frequency of other disease and disorder of Eye, Oral, Respiratory, Gastrointestinal, Genitourinary, Musculoskeletal were 31.4% (72), 22.2% (51), 24.1% (55), 41.8% (96), 31% (71), 62% (142) respectively. About 52.4% (120) were immunized and among them 13.1% were single vaccinated and 39.3% were multiple vaccinated. From 87.8% (201) married participants 35% (70) were having birth control methods, whereas most of them were dependent on pills 55.6%. On the side of female participants only, 9.7% (12) were pregnant, 16% (20) were reported painful period and 3.5% (8) were noted for breast discharge. Conclusion: The outcome of this study will give an authentic view about the Santals current health status and will draw the attention of the authority in order to make the available public health intervention and medical care available for not only them but also for other vulnerable tribal communities. This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh. 0012-01-01T00:00:00Z http://dspace.ewubd.edu:8080/xmlui/handle/123456789/1625 Evaluation of the Quality Control Parameters of Two Different Brands (Losucon and Dieta) of Glimepiride Tablets Available in Bangladesh Sikder, Samiul Islam Evaluation of the quality control parameter is always a better way for the understanding of the quality of local brands. Thus, the purpose of this research work was to determine the physical quality control parameter and the potency of two different brands (Losucon and Dieta) of glimepiride 2mg tablets (Two batches of each) which is used for the treatment of type II diabetes.According to the research study all the tablets showed a percentage weight variation within the range and meet the specification of USP. Thicknesses test of all the tablets of two different brands represents variable results but was also within acceptance range. All the tablets of these two brands had hardness lower than the standard value of 4 kg which can cause breakdown of tablets during use and transport. All the tabletsmeet the specification for disintegration time in accordance to BP. Average percent dissolution of all the batches meet the specification range. But some tablets individually were not dissolved 80% within 30 minutes. Both batches of Losucon meet the specification of potency (103.67% and 108.47%) according to BP and USP where the batches of Dieta had failed. All the test result were confirmed with the calculation of their standard deviation. As the friability study could not be performed due to some technical faults, further research for assuring the quality of drug in the local market should to be conducted. This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh. 0012-01-01T00:00:00Z