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Cytotoxic and Antioxidant Evaluation of Methanolic Extract of Aglaonema Hookerianum

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dc.contributor.author Arnob, Samin Yasar
dc.date.accessioned 2015-12-20T05:02:37Z
dc.date.available 2015-12-20T05:02:37Z
dc.date.issued 12/12/2014
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/1586
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh en_US
dc.description.abstract Aglaonema hookerianum is an herb found in the forests of Sylhet, Chittagong and Chittagong Hill Tracts. The species is traditionally used in the treatment of cirrhosis, flatulence, hyper acidity (gastritis) and tetanus and in stomachache, conjunctivitis and constipation by various communities of the region. The objective of the study was to evaluate the methanolic extract of Aglaonema hookerianum of whole plant for antioxidant activity and cytotoxic activity. The antioxidant activity of crude methanolic extract of Aglaonema hookerianum was evaluated by reducing power assay method. The color change was determined with the UV spectrophotometer. Values of Concentration against Absorbance was plotted to prepare a curve for the extract and standard ascorbic acid. The results indicate that as the concentration increases, absorbance increases proportionately. When the results are compared with the standard, the increase in reducing power is slightly less than the standard. This suggests the presence of bioactive compounds having antioxidant activity but is not potent at the required concentration. The crude methanolic extract of Aglaonema hookerianum was also screened for cytotoxic activity using brine shrimp lethality bioassay. The nauplii were treated with different concentration of the extract and the standard Tamoxifen. From the curve of % Mortality against Log of Concentration, LC50 value was determined. The LC50 value of Tamoxifen and the extract was 13.38 μg/ml and 44.8 μg/ml respectively which indicates the extract is less potent than the standard but possesses significant cytotoxic activity as substances less than 1000 μg/ml is presumed to possess cytotoxic activity. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00354
dc.subject Aglaonema hookerianum, Cytotoxic assay, Antioxidant assay, Brine shrimp lethality bio-assay, en_US
dc.title Cytotoxic and Antioxidant Evaluation of Methanolic Extract of Aglaonema Hookerianum en_US
dc.type Thesis en_US


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