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In-vitro Comparative Dissolution Study of Different Brands of Ranitidine Hydrochloride Tablets Available in Bangladesh Tablets Available in Bangladesh

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dc.contributor.author Sultana, Razia
dc.date.accessioned 2016-09-21T03:13:38Z
dc.date.available 2016-09-21T03:13:38Z
dc.date.issued 7/20/2016
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/1826
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract Branded drug products are normally expensive than locally marketed drug product of region of pharmaceutical companies. Generic substitution is very common in underdeveloped and developing counties including Bangladesh. The aim of the present was to evaluate and compare dissolution pattern of locally branded drug product of Ranitidine HCl (Zantac®) marketed by Glaxo Smith Kline Bangladesh Ltd. I took two brands of Ranitidine tablets available in Bangladesh as well as Zantac® were collected from a reputed pharmacy store in Dhaka. Six tablets from each of the brands were used for in vitro dissolution study. Cumulative drug release was measured up to 50 minutes for all two brands named Ethidine and Inseac and then all two brands were compared with innovator brand. The drug release pattern is not an indicator of drug efficacy in the body. Comparison of the dissolution profiles was carried out by calculation of the similarity factor and difference factor. The study was carried out at pH 7.4 normal range and water is used as media and then it was calculated for the values of factors. It was ran for 50 minutes with the intervals of 10 minutes and found the results provided previous discussion. The influence of pH was ignored in this study. The result may vary with them due to API quality, formulation factors and other things. In this study, comparisons of dissolution profiles of Ranitidine HCl oral formulations were made between three generic products. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00476
dc.subject Percentage of Release, Ranitidine (Zantac®), Inseac, Ethidin, Comparison of dissolution study. en_US
dc.title In-vitro Comparative Dissolution Study of Different Brands of Ranitidine Hydrochloride Tablets Available in Bangladesh Tablets Available in Bangladesh en_US
dc.type Thesis en_US


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