dc.contributor.author |
Sultana, Razia |
|
dc.date.accessioned |
2016-09-21T03:13:38Z |
|
dc.date.available |
2016-09-21T03:13:38Z |
|
dc.date.issued |
7/20/2016 |
|
dc.identifier.uri |
http://dspace.ewubd.edu/handle/2525/1826 |
|
dc.description |
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. |
en_US |
dc.description.abstract |
Branded drug products are normally expensive than locally marketed drug product of
region of pharmaceutical companies. Generic substitution is very common in underdeveloped
and developing counties including Bangladesh. The aim of the present was to
evaluate and compare dissolution pattern of locally branded drug product of Ranitidine
HCl (Zantac®) marketed by Glaxo Smith Kline Bangladesh Ltd. I took two brands of
Ranitidine tablets available in Bangladesh as well as Zantac® were collected from a
reputed pharmacy store in Dhaka. Six tablets from each of the brands were used for in
vitro dissolution study. Cumulative drug release was measured up to 50 minutes for all
two brands named Ethidine and Inseac and then all two brands were compared with
innovator brand. The drug release pattern is not an indicator of drug efficacy in the body.
Comparison of the dissolution profiles was carried out by calculation of the similarity
factor and difference factor. The study was carried out at pH 7.4 normal range and water
is used as media and then it was calculated for the values of factors. It was ran for 50
minutes with the intervals of 10 minutes and found the results provided previous
discussion. The influence of pH was ignored in this study. The result may vary with them
due to API quality, formulation factors and other things. In this study, comparisons of
dissolution profiles of Ranitidine HCl oral formulations were made between three generic
products. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
East West University |
en_US |
dc.relation.ispartofseries |
;PHA00476 |
|
dc.subject |
Percentage of Release, Ranitidine (Zantac®), Inseac, Ethidin, Comparison of dissolution study. |
en_US |
dc.title |
In-vitro Comparative Dissolution Study of Different Brands of Ranitidine Hydrochloride Tablets Available in Bangladesh Tablets Available in Bangladesh |
en_US |
dc.type |
Thesis |
en_US |