Abstract:
Oxidative stress and decreased level of neurotransmitter (especially acetylcholine) are
main characteristics of Alzheimer’s disease (AD), a progressive neurodegenerative
disease. Increasing the function of acetylcholine by inhibiting acetylcholinesterase or
butyrylcholinesterase enzyme (both are responsible for the breakdown of
Acetylcholine) and reducing oxidative stress with antioxidants are most effective
treatment therapy of AD. Beside this atherothrombosis is a major cause of global life
threatening cerebral diseases. Traditionally Diospyros blancoi has widely known for
its medicinal values. Our aim is to investigate the cholinesterase inhibitory activities
as well as thrombolytic activities of the bark and leaves crude methanolic extracts
(CME) and other fractions in the treatment of AD and clotting disorder. The crude
methanol extract was prepared by cold extraction method and were assessed for
acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity by
the Ellman’s method. For thrombolytic activity clot lysis method were applied. The
results revealed that the CME of both bark and leaf have Cholinesterase inhibitory
activities as well as thrombolytic activities which may be useful in the treatment of
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh
